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Considering the relationship between GLP-1 signaling and behavioral symptoms characteristic of depression, it was shown that intracerebroventricular ( icv ) administration of both GLP-1 and exendin-4 enhances associative and spatial learning, while these effects are inhibited by a GLP-1R antagonist

10.1186/s13018-016-0475-x 15 ChenJ.HuQ.LuoY.LuoL.LinH.ChenD.et al (2022a)

Thus, the heme iron released intracellularly from heme transported by HPX enters the same low molecular-mass intracellular pool as does iron from iron-Tf and is utilized for DNA synthesis by ribonucleotide reductase for cell growth

Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME, et al